Biologically-synthesized zinc oxide nanoparticle-based α-synuclein nanoformulation mitigates Parkinson's disease progression in Drosophila melanogaster.
Parkinson's disease (PD) is a synucleinopathy characterized by the accumulation of alpha-synuclein (αS) amyloid aggregates and loss of dopaminergic neurons. Evidence suggests that PD originates in intestine and progresses to brain via the vagus nerve. Thus, initially, the potential of orally-fed αS pre-formed fibrils (...