Sun-Ho Lim

Comparison of 3 guideline lipid emulsion regimens for local anesthetic systemic toxicity: an in silico study of bolus duration, total dose, and treatment delay in intravenous bupivacaine overdose.

Purpose Lipid emulsion is the only specific antidote for local anesthetic systemic toxicity, but no dose-finding study has been conducted. We compared 3 published regimens and alternative schedules that deliver the same dose in different ways using a human model of intravenous bupivacaine overdose. Methods A 14-compa...