Transcriptomic Profiling of Adhesion GPCRs in Pancreatic Adenocarcinoma Identifies ADGRG7 and ADGRF1 as Novel Diagnostic Biomarkers and Therapeutic Targets
A highly distinct aGPCR dysregulation signature characterized by the massive upregulation of ADGRG7 and ADGRF1 is identified within the PAAD microenvironment, highlighting them as promising diagnostic biomarkers and actionable therapeutic targets for overcoming TME-mediated immunosuppression.