Sung-Jun Kwon

Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids

Vascularized liver organoids are developed by integrating human induced pluripotent stem cell (iPSC)–derived hepatoblasts and endothelial cells into decellularized scaffolds functionalized with an anti-CD31 aptamer–based vascular coating agent (VCA) to establish a comprehensive framework for generating physiologically relevant liver tissues from iPSCs and demonstrate the utility of spatial transcriptomics for uncovering regenerative mechanisms.