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Sungsool Wi

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Sep 2026

Zn2+-Induced Dissociation of Transthyretin Tetramers Generates Toxic, Seeding-Active Misfolded Oligomers

The aggregation of transthyretin (TTR) is a hallmark of ATTR amyloidosis. Accumulating evidence suggests that metal ions, particularly Zn2+, promote TTR aggregation; however, the molecular mechanism underlying Zn2+-induced misfolding remains poorly understood. Here, we present a comprehensive biophysical characteriza...

R. Irving, Anvesh K. R. Dasari, Sy Duke et al. · 0 citations
Open access Aug 2026

Effects of Cholesterol on Nanodisc Formation and Magnetic Alignment in DMPC and Glycyrrhizic Acid Systems Probed by 31P and 14N Solid-State NMR

Nanodiscs and bicelles are widely used as membrane mimetics for structural studies of membrane-associated systems. Studies have reported that their magnetic alignment behavior and phase stability are highly sensitive to composition and temperature. In this study, we systematically investigate the effects of cholesterol...

Md Rokonujjaman, Sungsool Wi, A. Ramamoorthy · 0 citations

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