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Author

Sunil Guharajan

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Open access Sep 2026

dubTAGs enable on-demand stabilization for tunable and reversible control of endogenous protein levels

Precise and rapid control over cellular protein levels is essential to dissect complex biological systems. Chemical genetic approaches such as dTAG, in which a target is fused to a degron tag (FKBP12F36V) and degraded upon small molecule-mediated recruitment of E3 ligases, have enabled rapid and tunable control over pr...

Sunil Guharajan, Xiang-Yang Song, S. Sengupta et al. · 0 citations

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