l-Asparaginase is an essential chemotherapeutic enzyme used to treat acute lymphoblastic leukaemia and certain lymphoid malignancies; however, its clinical use can be limited by adverse effects linked to immunogenicity and undesirable l-glutaminase activity. In this study, a novel glutaminase-free l-asparaginase from L...
Thanapon Charoenwongpaiboon, K. Wangpaiboon, Y. Srichompoo et al.· RSC Advances· 0 citations
ABSTRACT Natural compounds with anti‐inflammatory properties are increasingly explored as therapeutic agents due to their lower risk of side effects compared with conventional drugs. Fisetin, a dietary bioflavonol abundant in fruits and vegetables, exhibits anti‐inflammatory activity in several cell types, including mu...
Nattaya Onpan, C. Lorthongpanich, P. Kheolamai et al.· Cell Biology International· 0 citations
Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to therapeutic resistance and tumor recurrence. In non-small cell lung cancer (NSCLC), cancer stem cells (CSCs) have emerged as key contributors to tumor persistence and progression. However, accelerated CSC-targeted drug discovery...
P. Samart, Supasorn Chanthateyanonth, Napachai Rodboon et al.· Biomedicine & pharmacotherap...· 0 citations
Cancer‐associated fibroblasts (CAFs) are key drivers of tumor progression. This study examined how three‐dimensional (3D) culture, hypoxia, and cancer‐derived soluble factors influence the transformation of human mesenchymal stem cells (hMSCs) into inflammatory CAFs (iCAFs). hMSCs from bone marrow, placenta, and chorio...
Pimjai Chingsuwanrote, C. Lorthongpanich, P. Kheolamai et al.· Journal of Cellular Physiolo...· 0 citations
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