Amiodarone-induced disruption of thyroid hormone signaling derails patterning and epithelial-mesenchymal dynamics during chick hindlimb development.
Thyroid hormones (THs) regulate embryonic growth and tissue remodeling, yet their contribution to avian limb morphogenesis remains incompletely defined. We hypothesized that amiodarone-induced inhibition of TH signaling can disrupt chick hindlimb development by altering key patterning pathways and epithelial-mesenchyma...