Sex-dependent effects of clozapine on PV interneurons, PNNs, and behavior in a neurodevelopmental model with schizophrenia-relevant phenotypes.
Sex modulates both the clinical presentation of schizophrenia (SCZ) and treatment response, yet its impact on the neurobiology of antipsychotic (AP) action remains insufficiently understood. Clozapine (CLZ), the gold standard for treatment-resistant SCZ, shows sex-dependent effects in both clinical and preclinical sett...