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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Susanne Wegmann

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Open access Aug 2026

14-3-3/Tau molecular glues modulate in vitro tau condensation

The intrinsically disordered protein Tau is highly phosphorylated under pathological conditions, which, among others, results in Tau liquid–liquid phase separation (LLPS), followed by aggregation. The hub protein 14-3-3 regulates Tau protein solubility and prevents LLPS by binding with phosphorylated Tau residues pS214...

Maxime C. M. van den Oetelaar, Leandre M. Ravatt, Francisco Maqueda Zelaya et al. · 0 citations

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