Chalcone-Arylpiperazine Hybrids as Potential Antianxiety Agents: Synthesis, Biological Evaluation, Molecular Modeling, and Network Pharmacology Studies.
Chalcone-arylpiperazine hybrids represent a potentially valuable scaffold for antianxiety drug development, however, the mechanistic insights derived from computational studies require robust in vivo and mechanistic validation to confirm therapeutic relevance.