Open access
Aug 2026
Ionizable Cholesterol‐Integrated Lipid Nanoparticles for Efficient siRNA Delivery to Solid Tumors
This study develops a class of ionizable cholesterol derivatives by conjugating biocompatible dimethylated amino acids to cholesterol through a cleavable linker, thereby integrating the structural role of cholesterol and the pH‐responsive ionization of ions into a single molecule.
Suyoung Kang, Duc-Toan Nguyen, Sangyong Jon
· ChemMedChem · 0 citations