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Suzanne Claxton

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Open access Sep 2026

Microtubule-associated protein 1S phosphorylation regulates dynein-driven transport in the brain and synaptogenesis in neurons.

Cyclin-dependent kinase like 5 (CDKL5) is a serine-threonine kinase enriched in the mammalian brain whose loss of function causes a severe developmental and epileptic encephalopathy named CDKL5 Deficiency Disorder. We previously showed that CDKL5 phosphorylates the microtubule-associated protein MAP1S, but how this reg...

A. T. Lopes, Ondine Janiv, Suzanne Claxton et al. · 0 citations

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