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Syahrul Imran

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Open access Sep 2026

Enantioselective Synthesis of a Unique, Folded Α/Γ Oligomeric Peptide Incorporating cis-Γ-Aminobutyrolactone Acetic Acid (ABAA) Units

We report here a new asymmetric approach that provides γ-amino acids bearing a cis-butyrolactone constraint at the Cβ–Cγ bond, leading to a tetrapeptide based on alternating cis-γ-aminobutyrolactone acetic acid (ABAA) and L-leucine, starting from a singly epoxidized cyclohexene. To synthesize the constrained cis-γ-buty...

M. T. Mohd Ali, Muhamad Kamil Yaacob, Wan Hazwan Hamali et al. · 0 citations
Aug 2026

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies.

These integrated experimental and computational results demonstrate that the polyhydroquinoline scaffold represents a promising platform for developing next-generation antidiabetic therapeutics with enhanced efficacy and favorable safety profiles.

Sultan Muhammad, A. Latif, Aftab Alam et al. · 0 citations

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