Enantioselective Synthesis of a Unique, Folded Α/Γ Oligomeric Peptide Incorporating cis-Γ-Aminobutyrolactone Acetic Acid (ABAA) Units
We report here a new asymmetric approach that provides γ-amino acids bearing a cis-butyrolactone constraint at the Cβ–Cγ bond, leading to a tetrapeptide based on alternating cis-γ-aminobutyrolactone acetic acid (ABAA) and L-leucine, starting from a singly epoxidized cyclohexene. To synthesize the constrained cis-γ-buty...