Open access
Aug 2026
Hypoxia-induced stromal and immune remodeling in gastric carcinoma: correlation of Hypoxia-inducible factor 1-alpha (HIF-1 alpha) expression with cancer-associated fibroblast (CAF) subtypes and Programmed death-ligand 1 (PD-L1) expression
High HIF 1 alpha expression and inflammatory CAF predominance are strongly associated with aggressive clinicopathological features and increased PD L1 expression, supporting the existence of a coordinated hypoxia stroma immune axis in gastric carcinoma progression.
G. A. Sadique, M. S. Mamun, S. Biswas et al.
· medRxiv · 0 citations