Utility and limitations of 18F-fluciclovine PET for biopsy targeting in a nonenhancing diffuse glioma with a gliomatosis cerebri–like growth pattern: illustrative case
Contrast-enhanced MRI reflects blood-brain barrier (BBB) disruption rather than tumor biological activity, whereas 18 F-fluciclovine ( 18 F-FACBC) PET reflects amino acid metabolism independent of BBB integrity. The authors compared regional 18 F-FACBC uptake with histopathological and molecular findings in...