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Author

T. Al-Warhi

4 papers indexed here

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Open access Aug 2026

Development of isonicotinoyl-azole hybrids as potential InhA inhibitors for anti-tubercular activity.

The development of innovative treatment medicines that can overcome drug resistance and intracellular persistence is necessary since tuberculosis (TB) continues to be a significant worldwide health burden. In this work, series of hybrid compounds containing azole moieties, imine/semicarbazide linkers, and isonicotinoyl...

Wagdy M. Eldehna, Zainab M. Elsayed, M. Korycka-Machała et al. · 0 citations
Open access Aug 2026

Quinazolinone–triazole hybrids as multi-target-directed ligands for Alzheimer's disease: discovery of potent and selective MAO-B inhibitors with cholinesterase modulating activity

A new series of quinazolinone–triazole hybrids (QTHs, 5a–n) was designed, synthesized, and evaluated as potential multi-target-directed ligands for Alzheimer's disease. All synthesized compounds were screened against human monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). The obtained results revealed pronou...

Wagdy M. Eldehna, Ashraf K El-Damasy, Jaeyeop Lim et al. · 1 citation
Open access Sep 2026

Design and synthesis of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and in silico studies

The ongoing emergence of SARS-CoV-2 mutations underscores the urgent need for new antivirals that target key viral proteins. This study describes the design, synthesis, and evaluation of two series of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as inhibitors of the SARS-CoV-2 main protease (Mpro): 1,2,3-tria...

T. Al-Warhi, Md Sofequl Islam Mukim, Zainab M. Elsayed et al. · 0 citations
Open access Jul 2026

Design, synthesis and DFT analysis of a highly selective chromenylium based fluorescent probe for cellular imaging and selective detection of sulfite ions

Sulfite (SO32−) is a significant analyte that is frequently employed as a food and beverage sector preservative but its excessive consumption might lead to negative health effects. Therefore, it is important to develop ultra-sensitive and ultra-selective sulfite detection methods. Herein, we demonstrate the design, syn...

Kazma Batool, T. Al-Warhi, A. Şenol et al. · 1 citation

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