The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...
A. Aggarwal, S. Ognenovska, Timothy Ison et al.· bioRxiv· 0 citations
Despite effective viral suppression with antiretroviral therapy (ART), people with HIV (PWH) remain at increased risk of neurocognitive impairment and persistent neuroinflammation. Although neurons are not infected by HIV, they remain susceptible to the indirect effects of chronic infection, including exposure to viral...
T. Angelovich, Jessica J. Kivinen, Sarah J. Byrnes et al.· Viruses· 0 citations
Defective HIV proviruses make up the majority of the proviral reservoir across blood and tissue compartments and may contribute to chronic inflammation, antigen persistence, and neuropathology in ART-suppressed PWH.
Emily K Chalmers, Janna Jamal Eddine, Liam Yucel et al.· Current Opinion in HIV and A...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.