Open access
Aug 2026
Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging
Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used single-cell RNA sequencing data to show that...
Hiroshi Kobayashi, Shintaro Watanuki, Yusuke Shiozawa et al.
· Science Advances · 0 citations