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Author

T. Baubec

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Oct 2026

A modular platform for in cellulo target engagement profiling of chromatin reader inhibitors.

The dysregulation of acylation-reading bromodomain proteins is implicated in many diseases, making them important therapeutic targets. However, drug development is hindered by a lack of high-throughput cellular assays to measure target engagement and off-target binding in living cells. To address this gap, we developed...

Davide C. Recchia, Richard Cardoso da Silva, Mathilde Noël et al. · 0 citations
Open access Sep 2026

ChromID: A Protocol for Mapping Protein Chromatin Interactions in Living Cells

A proximity-labeling protocol for identifying the chromatin-dependent protein interactome associated with specific chromatin marks, termed ChromID, which preserves native chromatin organization and captures transient chromatin-associated interactions that are often lost during conventional affinity purification workflo...

Richard Cardoso da Silva, Douwe ten Bulte, T. Baubec · 0 citations

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