Author

T. Beaumont

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Open access Jul 2026

Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers

Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim for HCV vaccine development. Starting from a recombinant E1E2...

Joan Capella-Pujol, Fabian Mulder, F. Cannac et al. · Nature Communications · 1 citation