Systematic molecular characterization of human induced pluripotent stem cell (iPSC) lines carrying disease-associated mutations is needed to distinguish disease-related biology from variation in cell state, genomic integrity, and genome-editing history, yet such systematic characterization is uncommon. Here, we profile...
Le Qi, T. Bertucci, Susan Borden et al.· Neuron· 0 citations
Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...
P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al.· Nature Aging· 1 citation
Iterative Mapping of proteoforms provides insights into proteoform complexity at the single-molecule level, with implications for understanding protein regulation in neurodegenerative diseases and beyond.
James Joly, V. Budamagunta, Zheng-Jian Zhang et al.· Nature Methods· 1 citation
Treatment with splicing modulator compounds that promote MAPT exon 10 exclusion reduced 4R tau expression and decreased the accumulation of hyperphosphorylated tau (pTau) and oligomeric and insoluble tau proteoforms, thereby rescuing tau-associated neuronal toxicity.
M. Silva, Hannah Lindmeier, Paolo Pigini et al.· Science Translational Medici...· 1 citation· ⚡1
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