Author

T. Brusko

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Open access Oct 2026

Type 1 diabetes SIRPG risk variants increase SIRPγ expression and CD47 loss enhances CD8+ T cell cytotoxicity

Type 1 diabetes (T1D) risk variants within SIRPG influence transcript splicing and alter the expression of signal regulatory protein gamma (SIRPγ) on human T cells; however, the functional consequences of the risk variants remain poorly defined. Here, we demonstrate that peripheral blood mononuclear cells from individu...

Robert C. Sharp, Matthew E. Brown, Leeana D. Peters et al. · npj Autoimmunity · 0 citations

Open access Sep 2026

Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes

Effector CD8+ T cells are key drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, peripheral tissue phenotype, and receptor specificity. We analyzed human pancreatic lymph nodes (pLNs) using mass cytometry and single-cell RNA-seq (scRNA-se...

Leeana D. Peters, Howard R. Seay, Justin A. Smith et al. · Journal of Clinical Investig... · 1 citation

Open access Aug 2026

Bootstrap-enhanced regularization addressing multicollinearity and skewness in high-dimensional immunophenotyping data

The Bootstrap-Enhanced Regularization Method (BERM) is a robust approach for variable selection and coefficient estimation in complex biomedical datasets, achieving the highest overall balanced accuracy while maintaining competitive coefficient estimation performance across a range of simulated sparsity, noise, and dim...

Xiaoru Dong, Apoorva Goyal, Mu-Xuan Liang et al. · BMC Bioinformatics · 0 citations