Author

T. Cazzella

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Oct 2026

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two-cohort imaging-genetics study.

AIM Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibility by influencing stress responsivity, ne...

T. Cazzella, L. Fortaner-Uyà, Marco Paolini et al. · Psychiatry and Clinical Neur... · 0 citations

Open access Aug 2026

A Delphi-method-based consensus for clinical domains and assessment of the inflammatory subtype of major depressive disorder from the ASPIRE study.

BACKGROUND Elevated inflammatory biomarkers have been consistently associated with a subset of depressive symptoms, particularly atypical and energy-related features, as well as antidepressant treatment resistance. This evidence has supported the definition of an inflammatory subtype of major depressive disorder (ISMDD...

B. Vai, T. Cazzella, C. Monopoli et al. · Brain, behavior, and immunit... · 1 citation

Open access Jul 2026

Mapping generalizable brain-based depression subtypes across clinical, cognitive, and neurotransmitter dimensions

Two distinguishable clusters emerged, with one showing widespread cortical thinning, anergy-related symptoms, childhood trauma, and diabetes comorbidity, and one showing widespread cortical thinning, anergy-related symptoms, childhood trauma, and diabetes comorbidity.

F. Colombo, L. Fortaner-Uyà, T. Cazzella et al. · medRxiv · 0 citations