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Author

T. Conrads

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Sep 2026

Abstract A024: A plastic, MYC -dependent KRT17 +/ GATA6 + hybrid state drives chemoresistance and therapeutic vulnerability in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) progression is driven by cellular heterogeneity not fully captured by the classical (GATA6+) versus basal-like (KRT17+) model. Intermediary states are linked to aggression, but their characteristics remain unclear. Here, we deconstruct this heterogeneity using a KRT17/GATA6 fra...

Lyanne A. Delgado-Coka, Andrew E. Resnick, Jonathan D. Ogata et al. · 0 citations
Open access Jul 2026

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

An integrated proteogenomic pipeline combining single-cell RNA sequencing, combinatorial optimization, mass spectrometry–based proteomics, and immunohistochemistry is developed to systematically map the SCLC surfaceome of 49 tumors across 25 patients with relapsed SCLC and found claudin-3 (CLDN3) to be a consistently e...

Brett Schroeder, Jaehyun Choi, Alejandro A. Schäffer et al. · 0 citations

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