Author

T. Dileepan

3 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Oct 2026

Efficient detection of human antigen-specific CD4+ T cells with peptide-exchangeable HLA-DP4 tetramers and multiplexed magnetic enrichment.

The tremendous variation in human MHCII alleles is a barrier to using fluorophore-labeled peptide:MHCII tetramers to study antigen-specific CD4+ T cells. This is because matching of the MHCII molecule in the tetramer with each human subject is required. We show that fluorophore-labeled tetramers of peptides complexed t...

Shawn A. Mahmud, Grace D. Frechette, Lisa M. Burzenski et al. · JIM - Journal of Immunologic... · 0 citations

Sep 2026

Abstract B084: Tracking tumor-specific CD4 T cells in pancreatic cancer reveals an essential role for cognate interactions with myeloid cells in remodeling the tumor microenvironment following immunotherapy

Our study identified an antigen (Ag)-specific CD4 T cell population in a preclinical orthotopic model of pancreatic ductal adenocarcinoma (PDA) that, upon expansion, elicited robust antitumor control. We developed an affinity-enhanced MHC-II tetramer to follow the endogenous tumor-specific CD4 T cells during pancreat...

Eduardo Cruz-Hinojoza, Zoe C. Schmichen, Sindri M. Bonner et al. · Cancer Research · 0 citations

Open access Aug 2026

Tumor-specific CD4 T cells cooperate with myeloid cells to remodel the pancreatic tumor microenvironment and enable effective immunotherapy

T tumor-specific CD4 T cells are central mediators of effective immunotherapy in solid tumors, and human immunotherapy transcriptomics shows conserved Th1 programming and Treg destabilization as a feature of response.

Eduardo Cruz-Hinojoza, Zoe C. Schmiechen, Sindri M. Bonner et al. · bioRxiv · 0 citations