T. Durgawale

Molecular Docking and ADMET Profiling of Tinospora cordifolia Phytochemicals Against Dihydrofolate Reductase: An Integrated in Silico Docking, Drug-Likeness, DFT, and Molecular-Dynamics Prioritization Study

Background: Dihydrofolate reductase (DHFR) is a validated target in cancer, bacterial, and protozoal chemotherapy, but classical antifolates such as methotrexate are limited by toxicity and resistance. Tinospora cordifolia (Guduchi), a climber central to Ayurveda and the traditional medicine of South India, is a rich s...