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T. Gomard

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Open access Sep 2026

The phosphate exporter XPR1 promotes gasdermin D–independent mature IL-1β secretion

Interleukin (IL)-1β is a leaderless inflammatory cytokine that is not secreted via the classical endoplasmic reticulum-Golgi pathway. Instead, mature IL-1β secretion is classically associated with pyroptosis, a caspase-dependent inflammatory cell death mediated by gasdermin D (GSDMD) pore formation at the plasma membra...

N. Rémy, Charlotte Six, Sandrine Tury et al. · 0 citations

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