Subclinical reductions in cardiac output relate to cognitive decline. We examined the relationship between cardiac output and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease pathologies in 153 participants from the Vanderbilt Memory and Aging Project. Linear regression and linear mixed effects regression mo...
Amalia J. Peterson, Yun-Yi Sun, Dan-Dan Liu et al.· Journal of Alzheimer's Disea...· 0 citations
Medical computer vision presents unique challenges compared to natural images, largely due to the high dimensionality of the data (e.g., 3D and 4D imaging) and limited training samples. Certain medical imaging modalities, such as Diffusion-weighted Magnetic Resonance Imaging (dMRI) - a critical tool for examining brain...
Tian-Yuan Yao, Zhi-Yuan Li, Michael E. Kim et al.· Medical Image Analysis· 0 citations
Modeling neurodegenerative conditions in neural organoids presents a potential complement to existing preclinical translation pipelines. Prior neural organoid models have generally relied on human induced pluripotent stem cell (iPSC) lines containing disease-relevant alleles. However, this strategy limits temporal co...
A. Kjar, Hyosung Kim, Madeline R. Spetz et al.· ACS Chemical Neuroscience· 0 citations
Abstract. Purpose Normative modeling of quantitative brain measurements is being widely adopted as a promising method for charting population-level developmental trajectories and identifying abnormalities in groups and individuals. Generalized additive models for location, scale, and shape (GAMLSS) are a statistical fr...
Michael E. Kim, G. Rudravaram, Adam M. Saunders et al.· Journal of Medical Imaging· 0 citations
INTRODUCTION Alzheimer’s disease (AD) disproportionately affects women, but the underlying mechanisms are not fully understood. We compare sex-specific molecular changes across AD with and without dementia at single-cell resolution. METHODS We performed sex-stratified single-nucleus transcriptomic analysis of human AD...
An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
A single-nucleus transcriptomic atlas spanning the human lifespan is used to show that the dorsolateral prefrontal cortex exhibits non-linear, cell-type-specific transcriptional trajectories characterized by dynamic remodelling during development, relative stability in midlife and selective molecular reactivation in la...
Hui Yang, Tereza Clarence, Madeline R. Scott et al.· Nature· 4 citations
A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, and offers potential targets for therapeutic intervention.
Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse et al.· Nature· 6 citations
GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs, is introduced, showing that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.
V. Bashyam, G. Erus, Jun-Hao Wen et al.· 0 citations
High-dimensional, multimodal predictors and partially observed multivariate outcomes are common in psychometric research. However, existing regularization methods often do not accommodate hierarchical predictor structures and are primarily designed for univariate outcomes. We propose SHIM, a Bayesian framework for stru...
Zong-Yue Teng, Shu-Jie Ma, T. Hohman et al.· 0 citations
ASL-sCoV may serve as an important hemodynamic measure for identifying perfusion deficits tied to SVD burden and progression and could provide substantial insight into the longitudinal clinical consequences of SVD.
W. Robb, Ava M. Santner, Pan-Pan Zhang et al.· Stroke· 0 citations
Higher plasma p-tau217 levels were consistently associated with increased risk of clinical progression and accelerated cognitive decline, and support the potential of p-tau217 for prognostic model development, with direct implications for future trial design.
R. Buckley, D. Townsend, C. Birkenbihl et al.· Journal of the American Medi...· 3 citations
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