Author

T. Honma

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Open access Aug 2026

Small-molecule RAS/RAF inhibitors target RAS-driven cancers via allosteric RAF disruption

RAS, a frequently mutated cancer-driver gene, has been the focus of intensive research, with numerous inhibitors developed to target RAS and its signalling molecules. With the advent of approved subtype-specific RAS inhibitors targeting KRASG12C mutation, the development of RAS inhibitors that are effective regardless...

Y. Yoshikawa, Hirokazu Kubota, S. Matsumoto et al. · Nature Communications · 0 citations

2026

Exploring Nucleic Acid Structure and Function with Molecular Dynamics and Fragment Molecular Orbital Methods.

In this study, molecular dynamics simulations and fragment molecular orbital calculations of hairpin DNA and three types of G-quadruplexes, which are involved in transcription and translation in the absence and presence of tetraethylene glycol(EG4) as crowding molecules, provide insight into how crowding molecules shap...

Tatsuya Ohyama, H. Tateishi-Karimata, Naoki Sugimoto et al. · Methods in molecular biology · 0 citations