Author

T. Kanekiyo

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Open access Sep 2026

Human iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis

Summary The apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanistic underpinnings by which it alters human microglial function remain poorly understood. Here, we utilize CRISPR/Cas9-engineered isogenic human induced pluripotent stem cell-deriv...

Y. You, Son N. Nguyen, Sean D. Mann et al. · Research Square · 0 citations

Open access Sep 2026

Discovery and preclinical validation of a translationally optimized mitochondrial complex I modulator for Alzheimer’s disease

Findings establish mild modulation of mtCI as a therapeutic strategy to restore metabolic resilience and identify C273 as a promising disease-modifying candidate for AD treatment.

Sergey Trushin, Thi Kim Oanh Nguyen, Mark Ostroot et al. · npj Drug Discovery · 0 citations

Open access Aug 2026

Brain multiomic profiling identifies tau-related transcriptomic dysregulation in Alzheimer’s disease

A hypothetical model of dynamic brain gene expression changes that track with progressive Alzheimer’s disease proteostasis is proposed and found that a beneficial brain biochemical state of higher total tau and lower phospho-Tau is associated with increased levels of synaptic, DNA damage/repair, nucleic acid metabolism...

Stephanie R. Oatman, Zachary S. Quicksall, Xue Wang et al. · Brain Communications · 0 citations