Author

T. Karikari

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Open access Oct 2026

Brain region- and solubility-dependent proteomic signatures of neurofibrillary tangle pathology in Alzheimer's disease

Neurofibrillary tangles (NFTs) are a hallmark of Alzheimer's disease. However, the molecular basis underlying their spatial heterogeneity and biochemical complexity remain unclear. To address this, we performed mass spectrometry-based proteomic profiling of two neocortical regions with different susceptibilities to NFT...

X. Zeng, E. Abrahamson, W. G. Balogun et al. · medRxiv · 0 citations

Open access Aug 2026

Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies

INTRODUCTION: Biomarkers for monitoring disease activity and treatment response in peripheral neuropathies remain limited. Big tau, a high-molecular-weight isoform of tau, is predominantly expressed in the peripheral nervous system (PNS). We investigated serum levels of big tau, brain-derived tau (BD-tau), and neurofil...

L. Martín-Aguilar, F. González-Ortiz, H. Zetterberg et al. · medRxiv · 0 citations

Aug 2026

Association Between Plasma GFAP and Medial Temporal Atrophy and Cognition in Amyloid-Negative Cerebrovascular Disease.

In Aβ-negative cognitively impaired individuals with high cerebrovascular burden, elevated plasma GFAP is associated with medial temporal atrophy and cognitive decline, suggesting GFAP may capture astrocyte-reactivity relevant to vascular cognitive impairment beyond amyloid pathology.

M. S. Oliveira-Junior, M. Rodrigues, Livia Amaral et al. · Neurology · 0 citations