Author

T. Kuulasmaa

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Open access Aug 2026

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

It is demonstrated that downregulation of PLCG2, primarily in neurons, impairs synaptic function and elevates amyloid-β levels and Tau protein phosphorylation in neurons.

Audrey Coulon, F. Rabiller, M. Takalo et al. · Nature Genetics · 0 citations

Open access Aug 2026

C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression

Summary C9orf72 hexanucleotide repeat expansion (C9-HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). However, approximately half of the FTD patients are sporadic without a clear genetic background. To compare characteristics of microglia from different FTD subtypes, we g...

Hannah Rostalski, Tomi Hietanen, Dorit Hoffmann et al. · Stem Cell Reports · 1 citation