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Author

T. Lammens

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Open access Oct 2026

A false sense of circularity: hidden variability in RNase R enzymes confounds reliable circRNA validation

Circular RNAs (circRNAs) are an emerging class of RNA molecules involved in development and disease. They are generated through back-splicing from pre-mRNA. RNaseR treatment, which degrades linear RNA while preserving circRNAs, is widely used for circRNA validation and enrichment. This short report demonstrated differe...

Lotte Ulrix, J. De Waele, J. Vandesompele et al. · 0 citations

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