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Open access Sep 2026

Discovery of CDK8/19 inhibitors as lead compounds for IL-6–dependent lymphoma enabled by the formal synthesis of cortistatin A

A formal synthesis of cortistatin A, a marine-derived steroidal alkaloid with potent anti-angiogenic and antileukemic activities, was achieved via a unique synthetic strategy that leveraged a late-stage SmI2-mediated oxa-bridge translocation. The de novo–synthesized simplified analog CA411 was evaluated across 38 cell...

Wen-Jun Wang, Nan Zhang, Bai-Cheng Chen et al. · 0 citations
Aug 2026

Divergent Syntheses of Euphorbia Diterpenoids: A Relay Rearrangement Strategy Triggered by Pyridinium Ring Contraction.

Euphorbia diterpenoids are a structurally diverse class of natural products renowned for their potent biological activities. Inspired by biosynthetic 1,2-migrations, yet deliberately departing from these pathways, we developed a synthetic strategy that provides collective access to multiple distinct skeletal families t...

Ling-Ran Kong, Jun-Long Qin, Hang Yu et al. · 0 citations

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