Open access
Oct 2026
Intranasal immunization expressing S1 antigen can confer functionally sterile protection against an intranasal SARS-CoV-2 challenge in mice.
Currently approved COVID-19 vaccines have shown significant protective efficacy against disease onset and progression after SARS-CoV-2 infection. However, systemic immune responses induced by intramuscular vaccination have limited impact on protection of viral transmission. Intranasal vaccination is an important strate...
Hiroshi Ishii, Kosuke Miyauchi, Shigeyoshi Harada et al.
· Vaccine · 0 citations