Open access
Sep 2026
High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions
Endosomal NHE6 (SLC9A6) and NHE9 (SLC9A9) transporters are essential for maintaining pH homeostasis within endosomes and their dysfunction has been linked to neurological and neurodegenerative disorders. NHE6 and NHE9 are widely considered to function as electroneutral exchangers that couple the export of protons to th...
Jesper S. Hansen, Ashley C. W. Pike, Gamma Chi et al.
· Nature Communications · 0 citations