Open access
Aug 2026
C9orf72-associated and sporadic FTD patient iPSC-microglia show differences in phagocytosis and gene expression
Summary C9orf72 hexanucleotide repeat expansion (C9-HRE) is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (FTD). However, approximately half of the FTD patients are sporadic without a clear genetic background. To compare characteristics of microglia from different FTD subtypes, we g...
Hannah Rostalski, Tomi Hietanen, Dorit Hoffmann et al.
· Stem Cell Reports · 1 citation