Summary This study investigated the relationship between the gut microbiota and two obesity indicators, body mass index (BMI) and waist-hip ratio (WHR) in a well-phenotyped random population sample of 5846 participants. Associations were tested using multivariable-adjusted linear models and validated for BMI in an exte...
L. Yeo, J. Palmu, A. Havulinna et al.· iScience· 1 citation
The gut microbiome has been linked to cancer in many cross-sectional studies. These studies compared individuals with and without cancer, but they do not establish causation. Prospective cohort studies, with faecal samples collected before a cancer diagnosis, will be instrumental in assessing the role of the gut microb...
E. Vogtmann, Caroline Y. Um, S. Zouiouich et al.· The Lancet Microbe· 0 citations
Cancer remains a leading cause of morbidity and mortality worldwide, and the incidence of new cancer cases is rising. While established lifestyle factors such as smoking, obesity, and diet contribute to cancer risk, the gut microbiome has emerged as a hallmark of cancer. However, the role of the gut microbiome in cance...
E. Oosterhout, R. S. Leijdesdorff, O. Kambur et al.· medRxiv· 0 citations
Intracranial aneurysms (IA) and their rupture (subarachnoid haemorrhage, SAH) are a rare but serious complication of autosomal dominant polycystic kidney disease (ADPKD). Both genetic and environmental risk factors contribute to the pathogenesis of IA and SAH, but specific information on risk factors in the ADPKD popul...
L. Urpa, S. Osman, T. Visser et al.· medRxiv· 0 citations
It is shown that people who are diagnosed with cancer after microbiome sampling have microbiome alterations like those found in diagnosed cancer cases, albeit to a lower degree, across the four populations studied, indicating that the microbiome may evolve towards the one found in cancer well before cancer is diagnosed...
G. Vitali, J. Bjork, O. Kambur et al.· medRxiv· 0 citations
It is demonstrated that robust signatures of co-abundant species can be prospectively associated with mortality, diabetes, liver disease, and sepsis risk among Finnish adults in the FINRISK population cohort based on a 20-year follow-up.
Himmi Lindgren, Chandler Ross, M. Ruuskanen et al.· Bioinformatics· 0 citations
Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.
Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al.· Molecular Systems Biology· 1 citation
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