Selective modifications of native proteins provide powerful opportunities to study and manipulate biological systems, yet achieving site-selective functionalization remains challenging due to the surfeit of competing amino acids, often addressed by genetic engineering of target proteins. Ligand-directed protein modific...
A. Haim, Cassandra J. Henderson, M. Akdeniz et al.· Chemical Society Reviews· 0 citations
Late-stage functionalization (LSF) of peptides offers direct access to structurally diverse analogues, but developing general, chemoselective protocols remains challenging due to the complexity of peptide substrates and the vast number of reaction variables. Traditional optimization methods are slow and resource-inte...
N. Kaplaneris, Elia Savino, Zhen He et al.· ACS Catalysis· 0 citations
The results show that LLM-based agents can make rigorous, long-running optimization campaigns accessible to domain scientists without specialist setup, expanding the scope of SDLs.
Marcel Müller, Jia-Ru Bai, W. Gottstein et al.· 0 citations
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