T. Pawlik

Recurrence After Resection of Colorectal Liver Metastases and Its Impact on Survival: A Multistate Model-Based, Multi-institutional Observational Cohort Study.

BACKGROUND Conventional survival analyses cannot fully account for recurrence as an intermediate event that dynamically influences subsequent mortality. Multistate models (MSMs) enable explicit modeling of transitions between clinically relevant disease states; however, their application among patients undergoing resec...

Hepatic Ischemia-Reperfusion Injury in Liver Transplantation: Molecular Mechanisms.

BACKGROUND Hepatic ischemia-reperfusion injury (HIRI) remains a major determinant of graft dysfunction and adverse outcomes in liver transplantation, particularly in the context of extended criteria donors. The complex interplay between metabolic disruption, oxidative stress, endothelial dysfunction, and immune activat...

Perforated and Complicated Cholecystitis: A Narrative Review of Diagnosis, Management, and Differentiation from Gallbladder Cancer.

Perforated cholecystitis is a diagnostically challenging and potentially life-threatening condition and greater recognition of the features distinguishing perforation from gallbladder malignancy may facilitate earlier diagnosis and improve outcomes.

Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer

Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Data from patients who underwent curative-intent resection for pancre...

Reevaluating Certificate-of-Need: Outcomes after Gastrointestinal Cancer surgery.

Con regulation was associated with greater concentration of GI cancer surgery at higher-volume, higher-market-share hospitals, but not with differences in adjusted perioperative outcomes.

Gata4 regulates fibroblast migration in a fibroblast-source-dependent manner under physiological matrix stiffness

Fibroblast migration contributes to the spatial organization of tissue repair and extracellular matrix remodeling, but the transcriptional mechanisms regulating this process under physiologically relevant mechanical conditions remain incompletely understood. We investigated whether GATA4 regulates fibroblast migration...

External Validation of the Comorbid Operative Risk Evaluation Score Among Medicare Beneficiaries Undergoing Major Gastrointestinal Surgery.

BACKGROUND Accurate risk adjustment is essential in gastrointestinal surgery, particularly among older adults. The surgery-specific Comorbid Operative Risk Evaluation (CORE) score demonstrated greater in-hospital mortality discrimination than conventional comorbidity indices in its derivation study, but its performance...

Inaccessible mental health care is a risk factor for risky drinking behaviors among cancer survivors: an All of Us survey-based cohort study

Access to mental health care services and the impact on substance use among cancer survivors has not been well-defined. Patients with cancer may be at particular risk of mental health challenges and excessive alcohol consumption. We sought to characterize the impact of mental health care access on drinking behaviors am...

Buffering the burden: health behaviors, mental distress, and sex disparities in U.S. cancer caregivers.

PURPOSE Cancer caregivers experience heightened psychological distress, yet the cumulative impact of modifiable health behaviors on mental distress remains understudied. We evaluated the association between individual and cumulative protective factors and frequent mental distress (FMD) among U.S. cancer and non-cancer...

Decoding osteosarcoma mechanobiology: PIEZO channels in tumor progression, immune remodeling, and pain

Impact of recurrence on survival after gastric cancer curative surgery: a retrospective, single center, multistate model analysis.

BACKGROUND Recurrence is the strongest determinant of mortality after curative gastrectomy for gastric cancer. Conventional Cox models do not explicitly account for recurrence as an intermediate event. Multistate models (MSMs) allow dynamic estimation of transition-specific risks across clinically relevant disease stat...

Association of Sleep Duration With Mental and Physical Health Measures Among Cancer Survivors.

PURPOSE Sleep disturbance is prevalent with chronic diseases and poor health. However, evidence evaluating these associations and their variation by cancer status remains limited. We sought to examine the association between sleep duration and mental and physical health measures by cancer history. METHODS Adults part...