4CMenB vaccine is authorized for protection against serogroup B invasive meningococcal disease (IMD). This study synthesized real-world evidence (RWE) data on effectiveness and impact of 4CMenB vaccine. A systematic search identified RWE on vaccine effectiveness (VE) and vaccine impact of 4CMenB in infants, children and adolescents. A meta-analysis was conducted of 4CMenB VE against serogroup B-IMD in infants and children. The primary meta-analysis used a random-effects model on data from five studies from five countries reporting VE in fully vaccinated infants and children, and estimated pooled VE at 79.7% (95% confidence interval 70.4, 86.1). In sensitivity analyzes, inclusion/exclusion of studies from the primary analysis did not materially change the results. Age-specific data in adolescents were summarized qualitatively. Data identified from Australia reported high effectiveness and impact in adolescents. This meta-analysis provides evidence of high 4CMenB VE against serogroup B-IMD in fully vaccinated infants and children across different geographic regions. Clinical trial registration: N/A.
Pavo Marijic, Katarzyna Jamróz-Dolińska, W. Margas et al.· npj Vaccines· 0 citations
BACKGROUND
Invasive meningococcal disease (IMD) is a vaccine-preventable, serious disease. In 2023-2024, the United States (US) Advisory Committee on Immunization Practices (ACIP) proposed revisions to the adolescent meningococcal vaccine schedule. This survey aimed to understand healthcare professionals' (HCPs') perspectives on these revisions and the potential role of the meningococcal serogroups A, B, C, W, Y (MenABCWY) vaccine.
METHODS
An online survey was conducted in May - June 2025 among US HCPs who regularly recommend meningococcal vaccines for 16-23-year-old patients. Responses were analyzed descriptively.
RESULTS
Of 302 HCPs, 73.2% felt the MenABCWY vaccine provides significant value to the meningococcal vaccination program, and almost half preferred a two-dose MenABCWY schedule over the ACIP recommendation, wherein a MenABCWY dose is followed by a MenB dose. Most HCPs indicated concern with removing MenACWY vaccination for 11-12-year-olds (84.8%). Comparatively, fewer were concerned about changing the MenB vaccine recommendation from shared clinical decision-making to risk-based (60.6%) and administering the second MenB dose closer to college entry (48.7%).
CONCLUSIONS
While HCPs were receptive to revisions that simplify the vaccine schedule, this was not without concerns. The adolescent vaccination platform is essential to ensure continued protection against IMD; any changes will require clear, evidence-based guidance.
O. Herrera-Restrepo, Laurie Batchelder, T. Pinto et al.· Expert Review of Vaccines· 0 citations
