Author

T. Poussaint

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Open access Aug 2026

A Phase I Trial of the ADAM-10 inhibitor, INCB007839, in Children with Recurrent/Progressive High-Grade Gliomas: A Report from the Pediatric Brain Tumor Consortium (PBTC-056)

Pediatric high-grade gliomas (pHGGs), including diffuse midline glioma (DMG) and diffuse intrinsic pontine glioma (DIPG), are the leading cause of central nervous system tumor-related morbidity and mortality in children. Neuronal activity promotes pHGG growth; one key mechanism is neuronal activity-regulated shed...

Alicia C. Lenzen, Sonia Partap, C. Billups et al. · Neuro-Oncology Pediatrics · 0 citations

Open access Aug 2026

Improved Deep Learning Segmentation of Pediatric Diffuse Midline Gliomas After Treatment.

Training DMG segmentation models with post-treatment scans substantially improves performance in longitudinal clinical trial imaging, enabling more accurate volumetric tracking and response assessment.

John Zielke, F. Mussa, A. Zapaishchykova et al. · AJNR. American journal of ne... · 0 citations