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Review Sep 2026

Targeting the Orai1 CRAC channel: translating molecular insights into therapeutic progress.

INTRODUCTION The Ca2+ release-activated Ca2+ (CRAC) channel, triggered by the interaction between the Ca2+ sensor STIM1 and Orai1, is the primary mediator of store-operated calcium entry (SOCE). Dysregulation of this process drives numerous human pathologies, particularly immune disorders and cancer hallmarks. Due to i...

I. Jardín, Alvaro Macías-Díaz, Vanesa Jimenez-Velarde et al. · 0 citations
Open access Aug 2026

Isoform-Specific Modulation of PI3K/Akt1 Signaling by Orai Channels in Estrogen Receptor-Positive Breast Cancer.

The phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is a fundamental intracellular axis that integrates extracellular stimuli to orchestrate essential cellular processes. The activation of Akt1 represents a key determinant of aggressiveness in estrogen receptor positive (ER+) breast cancer, a process closely ass...

Alvaro Macías-Díaz, J. López, Manuel Fuentes-Mateos et al. · 0 citations

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