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T. Soga

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Open access Sep 2026

499. Chronic stress impairs synaptic central metabolism in the prefrontal cortex, driving depression-related behaviors in mice

It is demonstrated that chronic stress disrupts central energy metabolism at prefrontal cortical synapses, driving to synaptic pathology and behavioral vulnerability and highlighting synaptic metabolic pathways as promising pharmacological targets for the treatment of stress-related psychiatric disorders.

H. Nagai, K. Ota, C. Numa et al. · 0 citations
Jul 2026

Plasma metabolomic signatures of heterogeneous multimorbidity trajectories in ageing: a population-based cohort study.

Findings implicate amino acid metabolism, redox balance, and microbiome-host interactions as candidate biological pathways underlying heterogeneous patterns of age-related disease accumulation, and warrant replication in independent cohorts.

Ryota Toki, Chisato Iba, Yûki Omoto et al. · 0 citations

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