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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

T. Sprink

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Open access Oct 2026

Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR

Mechanosensitive channels are central to cellular responses to membrane tension, yet the structural basis of their gating remains incompletely understood. Here, we determine the structures of wild-type and Gly22→Ser (G22S) mutants of MscL from Escherichia coli (EcMscL) by cryogenic electron microscopy (cryo-EM) in pept...

Tao-Ran Xiao, Alexandra Kovinko, C. Shi et al. · 0 citations
Open access Sep 2026

Ligand-induced activation of RyR1 in native membranes

Synchronized calcium release through arrays of the ryanodine receptor RyR1, fundamental to skeletal muscle excitation-contraction coupling, is achieved through the mechanical interaction of RyR1s and voltage-sensing receptors DHPR that activate RyR1s in response to action potentials. The calcium release is enhanced thr...

Vasilii Mikirtumov, Sabrina Golusik, Rui-Feng Huo et al. · 0 citations

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