Author

T. Takla

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Open access Aug 2026

Domain-Specific Cognitive Associations With Standing Balance in Multiple Sclerosis

Background: Balance impairments and cognitive deficits are both prevalent in individuals with multiple sclerosis (MS) and contribute to elevated fall risk. Although prior studies have examined global cognition and balance, few have investigated the relation between specific cognitive domains and balance performance und...

P. Monaghan, M. VanNostrand, T. Takla et al. · International Journal of MS... · 0 citations

Open access Sep 2026

Genome-wide CRISPRi screen in human iNeurons identifies novel negative mTOR regulator genes associated with focal cortical dysplasia.

Focal cortical dysplasia (FCD) is a common cause of focal epilepsy that typically results from brain mosaic mutations in the mTOR cell signaling pathway. To identify new potential FCD genes, we developed an in vitro CRISPRi screen in human neurons and used FACS enrichment based on the FCD biomarker, phosphorylated S6 r...

Andrew M. Tidball, Jing-Hui Luo, J. C. Walker et al. · Neurobiology of Disease · 0 citations