Open access
Sep 2026
Heterologous Reconstitution of 4-Amidopentadienoate Biosynthesis Identifies the PKS Machinery Responsible for Warhead Formation
The biosynthetic origin of the APD warhead is established and a foundation for incorporating this privileged pharmacophore into engineered peptide scaffolds is provided for incorporating this privileged pharmacophore into engineered peptide scaffolds.
M. Tvilum, Jonas L. Veiler, Thomas T. Paulsen et al.
· bioRxiv · 0 citations