Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA)...
K. Wee, Eric J. Zhao, Cassidy Clemente-Jones et al.· British Journal of Haematolo...· 0 citations
BACKGROUND
Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large-scale evidence-based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
METHODS
We conducted a retrospectiv...
Samuel Sassine, Hallie Coltin, Sylvia Cheng et al.· Pediatric Blood & Cancer· 0 citations
Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is characterized by targetable kinase fusions with different tyrosine kinase inhibitors (TKIs) currently being investigated in clinical trials. While kinase domain (KD) mutations represent the primary mechanism of acquired resistance in Phi...
M. Rozendaal, L. Laramée, Aurélien Choblet et al.· Cancer Research· 0 citations
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