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Open access Oct 2026

Whole-genome and transcriptome analysis in relapsed/refractory non-Hodgkin lymphoma: Results from a multicentre precision oncology cohort.

Comprehensive genome and transcriptome profiling can inform the diagnosis, prognosis and management of relapsed/refractory (R/R) solid malignancies, yet its integration into clinical care has lagged despite strong biological rationale. We evaluated the clinical utility of whole genome and transcriptome analysis (WGTA)...

K. Wee, Eric J. Zhao, Cassidy Clemente-Jones et al. · 0 citations
Open access Sep 2026

Central Nervous System Tumors Among Infants in Canada: A Report From CYP-C.

BACKGROUND Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large-scale evidence-based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children. METHODS We conducted a retrospectiv...

Samuel Sassine, Hallie Coltin, Sylvia Cheng et al. · 0 citations
Sep 2026

Abstract PR005: Investigating mechanisms of resistance in Philadelphia chromosome-like acute lymphoblastic leukemia

Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL) is characterized by targetable kinase fusions with different tyrosine kinase inhibitors (TKIs) currently being investigated in clinical trials. While kinase domain (KD) mutations represent the primary mechanism of acquired resistance in Phi...

M. Rozendaal, L. Laramée, Aurélien Choblet et al. · 0 citations

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