T-cell and monocyte DNA methylation and Wnt dysregulation in common variable immunodeficiency: an exploratory study
It is found that CVID is associated with extensive, cell type-specific epigenetic remodelling, particularly in T cells, and Wnt signalling emerges as a recurrently altered pathway across DNA methylation, circulating proteins and gene expression, supporting Wnt-related mechanisms as a potential contributor to CVID immun...